Breakthrough science aimed at optimising healthspan. Naturally. Welcome to the nutritech revolution.
At L-Nutra, we’re spearheading a global movement to turn sick care into health care. We believe science should treat the source, not the symptom. We believe food – one of the few things you consume continually – is a key to health, longevity and preventing and curing disease.
We’re using groundbreaking science and natural, plant-based solutions to prove it. We believe these solutions - combined with AI technology, lifestyle education and health professionals - can help everyone live healthier and longer.
In short, we’re here to change the world and usher in an entirely new kind of proactive health care. This is the nutritech revolution. We invite you to join us.
Fasting Mimicking Technology. The nutrition breakthrough of the century
The discovery of Fasting Mimicking Technology was a breakthrough in the Food as Medicine Movement. Discovered and developed at the Longevity Institute of the University of Southern California, our technology is plant-based nutrition that allows the body to enter into a beneficial fasting state without triggering the cells’ nutrient sensors. As the name suggests, it actually mimics fasting…while still allowing you to eat food. This nourished fasting fine-tunes cells, supports healthy aging, and eliminates the need to do a water-only starvation fast, which can have negative side effects.
Since organisms arose, the waxing and waning of their food resources has been a constant in nature. When food is scarce, this exerts compulsory pressure on all life forms to respond – or risk extinction. And so it is that through time, all species that survived have developed adaptive mechanisms during fasting that confer a survival advantage. When food is plentiful, the cells grow. When food is scarce, the cells stop growing and enter into a protective and recycling mode that conserves energy and optimizes cellular functions.
One key mechanism triggered by fasting is called autophagy. In fact, the discovery and description of autophagy mechanisms was so monumental to understanding cellular health that the discoverer won the 2016 Nobel Prize in Physiology or Medicine. As it turns out,
the mechanisms of autophagy and other survival processes are unsurprisingly similar in all species, down to their molecular pathways. From simple organisms such as yeast and fruit flies, to more complex organisms such as mice, other mammals, and humans, these pathways are conserved.
Specifically, during fasting, the body acts to conserve energy by minimizing any growth activities. This is achieved by shutting down the food signal sensors such as insulin-like growth factor-1 (IGF-1), the target of rapamycin (TOR), and protein kinase A (PKA). In scientific terms, this process is called “down-regulation of nutrient sensing pathways.” Fasting-induced reductions in IGF-1, TOR, and PKA signaling result in increased cellular maintenance and protection, including increased activation of stress resistance, and removal and replacement of old, worn out cellular parts. So, these fasting responses promote resilience.
Here lies one of nature’s greatest untold stories and L-Nutra’s vision. By continuing research into how fasting impacts us at the cellular level, and identifying the pathways through which fasting benefits our bodies, we can leverage our research to develop different products to promote health and longevity. Why not just fast? Despite the potential benefits, fasting is hard to do. For many, it’s not safe to do. So, our nutritechnology is focused on making fasting safer, effective, easier, and more practical while targeting specific outcomes. Our Fasting Mimicking Technology Platform encompasses the basic principles we’ve uncovered and continue to research about fasting, and allows us to develop different formulations targeted to different solutions. In general health and wellness, we have used it to develop and continuously improve the Fasting Mimicking Diet and related products. We’re also leveraging it to define and develop a novel class of fasting mimicking drugs to potentially prevent or treat a number of lifestyle-related chronic illnesses.
Using the power of autophagy and other survival mechanisms invoked by fasting while reducing the stress and improving safety is our goal. Developing specific nutritechnology products targeted for specific uses – that’s the power of the Fasting Mimicking Technology Platform.
The Path to Discovery
Fasting Mimicking Technology was developed at the Longevity Institute of the University of Southern California by a team of researchers led by Professor Valter Longo. After over a decade of research into the powerful health benefits of water fasting in mice, the researchers attempted to test water fasting in humans but quickly ran into compliance and safety issues that threatened their progress. However, the National Institutes of Health (NIH) recognized the importance of the project and granted millions of dollars to the team with the specific goal of developing Fasting Mimicking Technology (and thereby eliminating the need to test water-only fasting). The rest is history.
Today, based on promising results from our preclinical studies and early human trials, 16 top universities across the globe are testing a Fasting Mimicking Technology formulation for applications in longevity and disease prevention. Many institutions have also continued to work with L-Nutra in researching other Fasting Mimicking Technology formulations as therapies for the top five most lethal diseases known to mankind – diabetes, cancer, Alzheimer’s, and cardiovascular and autoimmune diseases. These institutions have helped tremendously in furthering our understanding of fasting and Fasting Mimicking Technology.
Ongoing, planned and completed clinical trials
For the latest updates on clinical trials, please visit L-Nutra Inc website